Immunology of Helicobacter pylori and prospects for vaccine

被引:11
作者
Blanchard, TG [1 ]
Czinn, SJ [1 ]
机构
[1] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Sch Med, Dept Pediat,Div Gastroenterol, Cleveland, OH 44106 USA
关键词
D O I
10.1016/S0889-8553(05)70137-0
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
An efficacious vaccine against Helicobacter pylori would provide a cost-effective means of preventing numerous gastric diseases. Several H, pylori animal models have been developed for use in the development of prototype subunit H. pylori vaccines. Using murine, ferret, and nonhuman primate systems, prophylactic and therapeutic vaccines have been shown to be effective at providing protection or in significantly reducing the H. pylori load in the gastric mucosa. Many of these vaccine prototypes have been delivered orally. Recent studies investigating alternative routes of antigen delivery and more traditional adjuvants systems provide encouraging data that a vaccine might someday be extended for efficacious in humans.
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页码:671 / +
页数:17
相关论文
共 85 条
[1]   Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity [J].
Appelmelk, BJ ;
SimoonsSmit, I ;
Negrini, R ;
Moran, AP ;
Aspinall, GO ;
Forte, JG ;
DeVries, T ;
Quan, H ;
Verboom, T ;
Maaskant, JJ ;
Ghiara, P ;
Kuipers, EJ ;
Bloemena, E ;
Tadema, TM ;
Townsend, RR ;
Tyagarajan, K ;
Crothers, JM ;
Monteiro, MA ;
Savio, A ;
DeGraaff, J .
INFECTION AND IMMUNITY, 1996, 64 (06) :2031-2040
[2]   Lipopolysaccharide of the Helicobacter pylori type strain NCTC 11637 (ATCC 43504): Structure of the O antigen chain and core oligosaccharide regions [J].
Aspinall, GO ;
Monteiro, MA ;
Pang, H ;
Walsh, EJ ;
Moran, AP .
BIOCHEMISTRY, 1996, 35 (07) :2489-2497
[3]   Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype [J].
Bamford, KB ;
Fan, XJ ;
Crowe, SE ;
Leary, JF ;
Gourley, WK ;
Luthra, GK ;
Brooks, EG ;
Graham, DY ;
Reyes, VE ;
Ernst, PB .
GASTROENTEROLOGY, 1998, 114 (03) :482-492
[4]  
BATTAN R, 1990, AM J GASTROENTEROL, V85, P1576
[5]  
BELL GD, 1992, ALIMENT PHARM THERAP, V6, P427
[6]   STIMULATORY EFFECTS OF HELICOBACTER-PYLORI ON HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF HELICOBACTER-PYLORI INFECTED PATIENTS AND HEALTHY BLOOD-DONORS [J].
BIRKHOLZ, S ;
KNIPP, U ;
OPFERKUCH, W .
ZENTRALBLATT FUR BAKTERIOLOGIE-INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY VIROLOGY PARASITOLOGY AND INFECTIOUS DISEASES, 1993, 280 (1-2) :166-176
[7]  
Blanchard TG, 1999, GASTROENTEROLOGY, V116, pA695
[8]   Qualitative and quantitative analysis of the local and systemic antibody response in mice and humans with Helicobacter immunity and infection [J].
Blanchard, TG ;
Nedrud, JG ;
Reardon, ES ;
Czinn, SJ .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (03) :725-728
[9]  
Blanchard TG, 1997, GUT, V41, pA63
[10]  
Blanchard TG, 1998, IMMUNOLOGY, V94, P22