Presence of ADAMTS13 activity in a patient with metastatic cancer and thrombotic microangiopathy

被引：17

作者：

Forman, RB

Benkel, SA

Novik, Y

Tsai, HM

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Div Hematol, Bronx, NY 10467 USA

[2] Beth Israel Med Ctr, New York, NY 10003 USA

来源：

ACTA HAEMATOLOGICA | 2003年 / 109卷 / 03期

关键词：

ADAMTS13; metastatic cancer; microangiopathic hemolysis; thrombocytopenia; thrombotic thrombocytopenic purpura;

D O I：

10.1159/000069291

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with metastatic cancers occasionally present with microangiopathic hemolysis and thrombocytopenia. A patient with metastatic adenocarcinoma of the colon and microangiopathic hemolysis was treated with plasma exchange for a presumptive diagnosis of thrombotic thrombocytopenic purpura (TTP). However, her condition continued to deteriorate and a determination of ADAMTS13 activity revealed that she did not have TTP. Despite similarity in clinical manifestation, microangiopathic hemolysis in patients with metastatic cancers may not be caused by ADAMTS13 deficiency and the role of plasma exchange in such patients should be re-evaluated. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：150 / 152

页数：3

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