Dicentric (17;18) in a case of atypical B-cell chronic lymphocytic leukemia

被引：4

作者：

Espinet, B

Sole, F

Lloveras, E

Abella, E

Besses, C

Woessner, S

Florensa, L

机构：

[1] Hosp Mar, Lab Referencia Catalunya, Lab Citol Hematol, IMAS,IMIM,Unitat Hematol 1973, Barcelona 08003, Spain

[2] Hosp Mar, IMAS, IMIM, Serv Hematol Clin,Unitat Hematol 1973, Barcelona, Spain

[3] Hosp Mar, IMAS, Escola Citol Hematol S Woessner, IMIM,Unitat Hematol 1973, Barcelona, Spain

来源：

CANCER GENETICS AND CYTOGENETICS | 2000年 / 121卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(00)00255-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a new dic(17;18)(p11.2;p11.2) in a 61-year-old male patient diagnosed with atypical B-cell chronic lymphocytic leukemia. The dic(17;18)(p11.2;p11.2) was detected in 90%, 10%, and 100% of metaphases in the peripheral blood, bone marrow and lymph node, respectively. Fluorescence in situ hybridization studies with chromosome 17 and 18 centromeric probes revealed the presence of two normal centromeres of both chromosomes 17 and 18. The centromere of one chromosome 17 was found together with the centromere of one chromosome 18, confirming the dicentric nature of the rearrangement. In addition, with the use of a 17p13.1 region probe, monosomy of the 17p13 region, where the Tp53 gene is located, was observed. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：194 / 197

页数：4

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