Thyroid hormone metabolism in obesity

被引：57

作者：

Roti, E

Minelli, R

Salvi, M

机构：

[1] Univ Parma, Ctr Studio Prevenz Diag & Cura Tireopatie, I-43100 Parma, Italy

[2] Univ Milan, Ist Endocrinol, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2000年 / 24卷 / Suppl 2期

关键词：

thyroid hormones; metabolism; obesity;

D O I：

10.1038/sj.ijo.0801293

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum thyroid hormone concentrations and their metabolic fate are within the normal range limits in obese subjects. Also serum TSH concentrations and its response to TRH are normal, suggesting that tissue availability of thyroid hormones is normally preserved in these subjects, In contrast, during caloric restriction serum T3 concentrations decrease as a consequence of its reduced production rate from peripheral deiodination of T4, Opposite, serum rT3 concentrations markedly increase as a result of its decreased metabolic clearance rate. During caloric overfeeding serum T3 concentration increase whereas serum rT3 concentrations decrease. In this condition the production rate of T3 increases, During caloric restriction and overfeeding serum T4 concentrations and its production and degradation are not modified.

引用

收藏

页码：S113 / S115

页数：3

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