Rapid changes of flow-mediated dilatation after surgical menopause

被引：33

作者：

Ohmichi, M ^{[1
]}

Kanda, Y ^{[1
]}

Hisamoto, K ^{[1
]}

Morishige, K ^{[1
]}

Takahashi, K ^{[1
]}

Sawada, K ^{[1
]}

Minekawa, R ^{[1
]}

Tasaka, K ^{[1
]}

Murata, Y ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Obstet & Gynecol, Osaka 5650871, Japan

来源：

MATURITAS | 2003年 / 44卷 / 02期

关键词：

flow-mediated dilatation; ovariectomy; menopause;

D O I：

10.1016/S0378-5122(02)00320-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives: Estrogen acts directly on endothelial nitric oxide synthase through a non-genomic mechanism, resulting in rapid dilatation of blood vessels. In this study, we examined the change of endothelial function after surgical menopause. Methods: In 20 subjects who underwent gynecological operations (ovariectomy (OVX) 12, sham (SHAM) operation 8), postoperative changes of flow-mediated dilatation (FMD) of the brachial artery were examined using ultrasonography. Postoperative changes of the response to nitroglycerin (NTG) were also studied in these patients. Results: In the OVX group, significant decreases of FMD were observed 1 week after the operation, although no changes were observed in the response to NTG. In the SHAM group, no remarkable changes of FMD or the response to NTG were observed after the operation. Conclusions: OVX influences endothelium-dependent vasodilatation within as little as 1 week. Therefore, it may be important to address the rapid changes of circulation after surgical menopause in order to prevent cardiovascular disease. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：125 / 131

页数：7

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