SOS-independent induction of dinB transcription by β-lactam-mediated inhibition of cell wall synthesis in Escherichia coli

被引：92

作者：

Pérez-Capilla, T

Baquero, MR

Gómez-Gómez, JM

Ionel, A

Martín, S

Blázquez, J

机构：

[1] Univ Autonoma Madrid, Ctr Nacl Biotecnol, Dept Biotecnol Microbiana, E-28049 Madrid, Spain

[2] Hosp Ramon & Cajal, Microbiol Serv, E-28034 Madrid, Spain

[3] CSIC, INTA, Ctr Astrobiol, Lab Evoluc Microbiana, Madrid, Spain

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 04期

关键词：

D O I：

10.1128/JB.187.4.1515-1518.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Transcription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the P-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation.

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页码：1515 / 1518

页数：4

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