Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors

被引:192
作者
Roche, A
Girish, BV
de Baère, T
Baudin, E
Boige, V
Elias, D
Lasser, P
Schlumberger, M
Ducreux, M
机构
[1] Inst Gustave Roussy, Serv Radiol Intervent, F-94805 Villejuif, France
[2] Inst Gustave Roussy, Serv Oncol Digest, F-94805 Villejuif, France
[3] Inst Gustave Roussy, Serv Chirurg Digest, F-94805 Villejuif, France
[4] Inst Gustave Roussy, Nucl Med Serv, F-94805 Villejuif, France
关键词
liver metastasis; digestive endocrine tumors; chemoembolization; carcinoid tumors; intra-arterial chemotherapy;
D O I
10.1007/s00330-002-1558-0
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Our objective was to report the outcome in patients with liver metastasis from endocrine tumors who underwent transarterial chemoembolization (TACE) as first-line non-surgical treatment. From January 1990 to December 2000, 14 patients with progressive unresectable liver metastases from digestive neuroendocrine tumor were treated with TACE (mean of 3.6 sessions) before any non-surgical treatment (somatostatin analogue, chemotherapy or interferon). Liver involvement was less than 50% in 11 patients. Size of the largest lesion ranged from 1.5 to 10 cm. Ten patients presented with carcinoid symptoms. The TACE was performed with Doxorubicin emulsified in Lipiodol and gelatin sponge particles. Symptomatic response upon flushes and/or diarrhea was complete in 7 of 10 cases and partial in 2 of 10 cases. An objective morphologic response was noted in 12 of 14 cases. The 5- and 10-year survival rate from diagnosis was 83 and 56%, respectively. Six patients were alive at the end of the study after 27-100 months from first TALE and 38-142 months from diagnosis. Three of them were successfully palliated for 55, 69, and 100 months with only TALE as treatment. Longterm palliation is possible in unresectable liver metastases from digestive neuroendocrine tumors with a few sessions of TACE as first-line and eventually exclusive treatment.
引用
收藏
页码:136 / 140
页数:5
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