A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase

被引：22

作者：

Aoyama, T

Satoh, T

Yonemoto, M

Shibata, J

Nonoshita, K

Arai, S

Kawakami, K

Iwasawa, Y

Sano, H

Tanaka, K

Monden, Y

Kodera, T

Arakawa, H

Suzuki-Takahashi, I

Kamei, T

Tomimoto, K

机构：

[1] Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Drug Discovery Res Labs, Tsukuba, Ibaraki 30026, Japan

[2] Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Biomed Res Labs, Tsukuba, Ibaraki 30026, Japan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 41卷 / 02期

关键词：

D O I：

10.1021/jm970540f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：143 / 147

页数：5

共 36 条

[11] EFFICIENT AND STEREOSELECTIVE SYNTHESIS OF J-104,118, A NOVEL, POTENT INHIBITOR OF SQUALENE SYNTHASE [J].

IWASAWA, Y ;

NONOSHITA, K ;

TOMIMOTO, K .

TETRAHEDRON LETTERS, 1995, 36 (41) :7459-7462

[12] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF J-104,118, A NOVEL, POTENT INHIBITOR OF SQUALENE SYNTHASE [J].

IWASAWA, Y ;

HAYASHI, M ;

NOMOTO, T ;

SHIBATA, J ;

MITSUYA, M ;

HIROTA, K ;

YONEMOTO, M ;

KAMEI, T ;

MIURA, K ;

TOMIMOTO, K .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (17) :1989-1994

[13] J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs [J].

Iwasawa, Y ;

Shibata, J ;

Mitsuya, M ;

Masaki, H ;

Hayashi, M ;

Kanno, T ;

Sawasaki, Y ;

Hisaka, A ;

Kamei, T ;

Tomimoto, K .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (04) :463-466

[14] Stereoselective synthesis of J-104,118 and J-104,123, novel potent inhibitors of squalene synthase [J].

Iwasawa, Y ;

Shibata, J ;

Nonoshita, K ;

Arai, S ;

Masaki, H ;

Tomimoto, K .

TETRAHEDRON, 1996, 52 (44) :13881-13894

[15]

IWASAWA Y, 1996, Patent No. 05169

[16] ISOPRENOID ADDITION TO RAS PROTEIN IS THE CRITICAL MODIFICATION FOR ITS MEMBRANE ASSOCIATION AND TRANSFORMING ACTIVITY [J].

KATO, K ;

COX, AD ;

HISAKA, MM ;

GRAHAM, SM ;

BUSS, JE ;

DER, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6403-6407

[17] PROTEIN FARNESYLTRANSFERASE INHIBITORS BLOCK THE GROWTH OF RAS-DEPENDENT TUMORS IN NUDE-MICE [J].

KOHL, NE ;

WILSON, FR ;

MOSSER, SD ;

GIULIANI, E ;

DESOLMS, SJ ;

CONNER, MW ;

ANTHONY, NJ ;

HOLTZ, WJ ;

GOMEZ, RP ;

LEE, TJ ;

SMITH, RL ;

GRAHAM, SL ;

HARTMAN, GD ;

GIBBS, JB ;

OLIFF, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :9141-9145

[18] INHIBITION OF FARNESYLTRANSFERASE INDUCES REGRESSION OF MAMMARY AND SALIVARY CARCINOMAS IN RAS TRANSGENIC MICE [J].

KOHL, NE ;

OMER, CA ;

CONNER, MW ;

ANTHONY, NJ ;

DAVIDE, JP ;

DESOLMS, SJ ;

GIULIANI, EA ;

GOMEZ, RP ;

GRAHAM, SL ;

HAMILTON, K ;

HANDT, LK ;

HARTMAN, GD ;

KOBLAN, KS ;

KRAL, AM ;

MILLER, PJ ;

MOSSER, SD ;

ONEILL, TJ ;

RANDS, E ;

SCHABER, MD ;

GIBBS, JB ;

OLIFF, A .

NATURE MEDICINE, 1995, 1 (08) :792-797

[19] Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine [J].

Lamothe, M ;

Perrin, D ;

Blotieres, D ;

Leborgne, M ;

Gras, S ;

Bonnet, D ;

Hill, BT ;

Halazy, S .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (12) :1291-1296

[20]

LANNERT KP, 1974, Patent No. 3855248

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