Mesenchymal stem cell features of Ewing tumors

被引：382

作者：

Tirode, Franck

Laud-Duval, Karine

Prieur, Alexandre

Delorme, Bruno

Charbord, Pierre

Delattre, Olivier

机构：

[1] Inst Curie, F-75248 Paris 05, France

[2] INSERM, Unite Genet & Biol Canc, U830, F-75248 Paris 05, France

[3] INSERM, Equipe ESPRIT EA3855, F-37032 Tours 1, France

[4] Univ Tours, Fac Med, F-37032 Tours 1, France

来源：

CANCER CELL | 2007年 / 11卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2007.02.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced Ewing cell lines converge toward that of mesenchymal stem cells (MSC). Moreover, upon EWS-FLI1 silencing, two different Ewing cell lines can differentiate along the adipogenic lineage when incubated in appropriate differentiation cocktails. In addition, Ewing cells can also differentiate along the osteogenic lineage upon long-term inhibition of EWS-FLI1. These in silico and experimental data strongly suggest that the inhibition of EWS-FLI1 may allow Ewing cells to recover the phenotype of their MSC progenitor.

引用

收藏

页码：421 / 429

页数：9

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