New virulence-activated and virulence-repressed genes identified by systematic gene inactivation and generation of transcriptional fusions in Bordetella pertussis

被引：83

作者：

Antoine, R ^{[1
]}

Alonso, S ^{[1
]}

Raze, D ^{[1
]}

Coutte, L ^{[1
]}

Lesjean, S ^{[1
]}

Willery, E ^{[1
]}

Locht, C ^{[1
]}

Jacob-Dubuisson, F ^{[1
]}

机构：

[1] Inst Pasteur, Inst Biol Lille, INSERM, U447, F-59019 Lille, France

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 20期

关键词：

D O I：

10.1128/JB.182.20.5902-5905.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An in silico scan of the partially completed genome sequence of Bordetella pertussis and analyses of transcriptional fusions generated with a new integrational vector were used to identify new potential virulence genes. The genes encoding a putative siderophore receptor, adhesins, and an autotransporter protein appeared to be regulated in a manner similar to Bordetella virulence genes by the global virulence regulator BvgAS. In contrast, the gene encoding a putative intimin-like protein appeared to be repressed under conditions of virulence.

引用

页码：5902 / 5905

页数：4

共 30 条

[1] Understanding signal transduction during bacterial infection
Akerley, BJ
Miller, JF
[J]. TRENDS IN MICROBIOLOGY, 1996, 4 (04) : 141 - 146
[2] Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis
Belisle, JT
Vissa, VD
Sievert, T
Takayama, K
Brennan, PJ
Besra, GS
[J]. SCIENCE, 1997, 276 (5317) : 1420 - 1422
[3] CHANG MC, 1992, GENE, V122, P175
[4] MOLECULAR-CLONING AND CHARACTERIZATION OF PROTECTIVE OUTER-MEMBRANE PROTEIN-P.69 FROM BORDETELLA-PERTUSSIS
CHARLES, IG
DOUGAN, G
PICKARD, D
CHATFIELD, S
SMITH, M
NOVOTNY, P
MORRISSEY, P
FAIRWEATHER, NF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (10) : 3554 - 3558
[5] de Rossi BNP, 1999, FEMS MICROBIOL LETT, V172, P9
[6] Neither the Bvg- phase nor the vrg6 locus of Bordetella pertussis is required for respiratory infection in mice
de Tejada, GM
Cotter, PA
Heininger, U
Camilli, A
Akerley, BJ
Mekalanos, JJ
Miller, JF
[J]. INFECTION AND IMMUNITY, 1998, 66 (06) : 2762 - 2768
[7] DELORENZO V, 1994, METHOD ENZYMOL, V235, P386
[8] ENTEROPATHOGENIC ESCHERICHIA-COLI
DONNENBERG, MS
KAPER, JB
[J]. INFECTION AND IMMUNITY, 1992, 60 (10) : 3953 - 3961
[9] EZZELL JW, 1981, MICROBIOS, V31, P171
[10] CLONING AND SEQUENCING OF A BORDETELLA-PERTUSSIS SERUM RESISTANCE LOCUS
FERNANDEZ, RC
WEISS, AA
[J]. INFECTION AND IMMUNITY, 1994, 62 (11) : 4727 - 4738

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