LTP and LTD vary with layer in rodent visual cortex

被引：40

作者：

Daw, N ^{[1
]}

Yan, R ^{[1
]}

Wang, XF ^{[1
]}

Fischer, Q ^{[1
]}

Yang, YP ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Ophthalmol, New Haven, CT 06520 USA

来源：

VISION RESEARCH | 2004年 / 44卷 / 28期

关键词：

ocular dominance plasticity; long-term potentiation; long-term depression; visual cortex;

D O I：

10.1016/j.visres.2004.09.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mechanisms of plasticity in the visual cortex have been studied with long-term potentiation (LTP), long-term depression (LTD) and ocular dominance plasticity (ODP). It is now possible to compare results from these three forms of plasticity using knockout mice, and also by pharmacological manipulations. A review of the literature shows that if both LTP and LTD are completely abolished, then ODP will also be abolished. In other situations, there is little correlation. We hypothesize that this lack of correlation occurs because the mechanisms for LTP and LTD vary with layer in the visual cortex, and results show that they do. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3377 / 3380

页数：4

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