Synthesis of α- and β-C-glycosides of N-acetylglucosamine

被引:21
作者
McGarvey, GJ [1 ]
Schmidtmann, FW [1 ]
Benedum, TE [1 ]
Kizer, DE [1 ]
机构
[1] Univ Virginia, Dept Chem, Charlottesville, VA 22903 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0040-4039(03)00818-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
As part of efforts to make available new, classes of bioactive C-glycoconjugates, D-glucosamine has been effectively converted into a series of 2-deoxy-2-amino-C-glycosides. This versatile approach is keyed by a remarkably effective metal catalyzed olefin isomerization of the isomeric C-allyl amino sugars which, in turn, are readily available via radical allylation of D-glucosamine. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3775 / 3779
页数:5
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