Mitochondrial estrogen receptors - new insights into specific functions

被引：86

作者：

Yager, James D. ^{[1
]}

Chen, Jin Q.

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2007年 / 18卷 / 03期

关键词：

D O I：

10.1016/j.tem.2007.02.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Estrogen receptor (ER) a and ERR are present in mitochondria but little is known about their contribution to the overall constellation of cellular responses to 17 beta-estradiol, which inhibits the early stages of apoptosis through membrane and mitochondrial, but not nuclear, ER signaling pathways. Whereas membrane ER signaling leading to inhibition of apoptosis involves the activation of protein kinase pathways, mitochondrial ER-mediated inhibition involves the direct and/or indirect activation of manganese superoxide dismutase by the mitochondrial ER.

引用

页码：89 / 91

页数：3

共 15 条

[1] Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications [J].

Chen, JQ ;

Yager, JD ;

Russo, J .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2005, 1746 (01) :1-17

[2] Mitochondrial localization of ERα and ERβ in human MCF7 cells [J].

Chen, JQ ;

Delannoy, M ;

Cooke, C ;

Yager, JD .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 286 (06) :E1011-E1022

[3] Functional analysis of genetic variation in catechol-o-methyltransferase (COMT):: Effects on mRNA, protein, and enzyme activity in postmortem human brain [J].

Chen, JS ;

Lipska, BK ;

Halim, N ;

Ma, QD ;

Matsumoto, M ;

Melhem, S ;

Kolachana, BS ;

Hyde, TM ;

Herman, MM ;

Apud, J ;

Egan, MF ;

Kleinman, JE ;

Weinberger, DR .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (05) :807-821

[4] The psychology behind the masks: Psychological responses to the severe acute respiratory syndrome outbreak in different regions [J].

Cheng, C ;

Tang, CSK .

ASIAN JOURNAL OF SOCIAL PSYCHOLOGY, 2004, 7 (01) :3-7

[5] Upregulation of mitochondrial respiratory complex IV by estrogen receptor-β is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage [J].

Hsieh, Ya-Ching ;

Yu, Huang-Ping ;

Suzuki, Takao ;

Choudhry, Mashkoor A. ;

Schwacha, Martin G. ;

Bland, Kirby I. ;

Chaudry, Irshad H. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006, 41 (03) :511-521

[6] Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms [J].

Kim, JK ;

Pedram, A ;

Razandi, M ;

Levin, ER .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6760-6767

[7] Activation of kinase pathways in MCF-7 cells by 17β-estradiol and structurally diverse estrogenic compounds [J].

Li, XR ;

Zhang, S ;

Safe, S .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2006, 98 (2-3) :122-132

[8] Functional estrogen receptors in the mitochondria of breast cancer cells [J].

Pedram, A ;

Razandi, M ;

Wallace, DC ;

Levin, ER .

MOLECULAR BIOLOGY OF THE CELL, 2006, 17 (05) :2125-2137

[9] Nature of functional estrogen receptors at the plasma membrane [J].

Pedram, Ali ;

Razandi, Mahnaz ;

Levin, Ellis R. .

MOLECULAR ENDOCRINOLOGY, 2006, 20 (09) :1996-2009

[10] Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer [J].

Razandi, M ;

Pedram, A ;

Levin, ER .

MOLECULAR ENDOCRINOLOGY, 2000, 14 (09) :1434-1447

← 1 2 →