Nonthrombogenic polymers - Designs and evaluation

被引：24

作者：

Nakabayashi, N

Ishihara, K

机构：

[1] Inst. for Med. and Dent. Engineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101, 2-3-10, Kanda-surugadai

来源：

MACROMOLECULAR SYMPOSIA | 1996年 / 101卷

关键词：

D O I：

10.1002/masy.19961010146

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

New nonthrombogenic polymers were designed with attention to the surface of biological membranes, that is, the surface was completely covered with phospholipids adsorbed from plasma. The polymers with phospholipid polar group, 2-methacryloyloxyethyl phosphorylcholine polymers, could interact with phospholipids in plasma selectively and strongly. The adsorbed phospholipids on the polymer surface were concentrated, organized each other and then formed a self-assembled biomimetic membrane surface. The surface showed excellent resistance for both protein adsorption and blood cell adhesion.

引用

页码：405 / 412

页数：8

共 11 条

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