Elevated thermostatic setpoint in postoperative patients

Background: The mechanism and clinical relevance of increased core temperature (Tc) after surgery are poorly understood. Because fever is used as a diagnostic sign of infection, it is important to recognize what constitutes the normal postoperative thermoregulatory response. In the current study the authors tested the hypothesis that a regulated increase in Tc setpoint occurs after surgery. Methods: The authors prospectively studied 271 patients in the first 24 h after a variety of vascular, abdominal and thoracic surgical procedures. Tc measured in the urinary bladder, skin-surface temperatures, thermoregulatory responses (vasoconstriction and shivering), and total leukocyte counts were assessed. In a subset of 34 patients, plasma concentrations of tumor necrosis factor, interleukin (IL)-6, and IL-8 were measured before and after surgery. Results: In the early postoperative period, the maximum increase in Te above the preoperative baseline averaged 1.4 +/- 0.8 degreesC (2.5 +/- 1.4 degreesF), with the Te peak occurring 11.1 +/- 5.8 h after surgery. Fifty percent of patients had a maximum Tc greater than or equal to 38.0 degreesC (100.4 degreesP) and 25% had a maximum Tc greater than or equal to 38.5 degreesC (101.3 degreesF), The progressive postoperative increase in Te was clearly associated with cutaneous vasoconstriction and shivering, indicating a regulated elevation in Tc setpoint. The elevated Tc was associated with an increased IL-6 response but not with leukocytosis, Maximum postoperative Tc was positively correlated with duration and extent of the surgical procedure. Conclusions: A regulated elevation in Tc setpoint (fever) occurs normally after surgery. The association between Tc elevation, extent and duration of surgery, and the cytokine response suggests that early postoperative fever is a manifestation of perioperative stress.