Redox modulation of the apoptogenic activity of thapsigargin

被引：3

作者：

Cerella, Claudia

Coppola, Simona

D'Alessio, Maria

De Nicola, Milena

Magrini, Andrea

Bergamaschi, Antonio

Ghibelli, Lina

机构：

[1] Univ Roma Tor Vergata, Dipartimento Biol, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, Cattedra Med Lavoro, I-00133 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Cattedra Med Lavoro, I-00168 Rome, Italy

来源：

SODIUM-CALCIUM EXCHANGE AND THE PLASMA MEMBRANE CA2+-ATPASE IN CELL FUNCTION: FIFTH INTERNATIONAL CONFERENCE | 2007年 / 1099卷

关键词：

thapsigargin; apoptosis; calcium; glutathione; nitric oxide;

D O I：

10.1196/annals.1387.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thapsigargin (THG), a selective inhibitor of endoplasmic reticulum (ER) Ca2+ -ATPases, causes the rapid emptying of ER Ca2+; in some cell types, this is accompanied by apoptosis, whereas other cells maintain viability. In order to understand the molecular determinants of such a different behavior, we explored the role of oxygen versus nitrogen radicals, by analyzing the apoptogenic ability of THG in the presence of inhibitors of glutathione or nitric oxide (NO) synthesis, respectively. We observed that oxygen radicals play a sensitizing role whereas nitrogen radicals prevent THG-dependent apoptosis, showing that the apoptogenic effect of THG is redox sensitive.

引用

页码：469 / 472

页数：4

共 5 条

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DALESSIO, 2004, FASEB J, V19, P1504

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