Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes

被引：79

作者：

Masaoka, T

Suzuki, H ^{[1
]}

Hosoda, H

Ota, T

Minegishi, Y

Nagata, H

Kangawa, K

Ishii, H

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan

[2] Keio Univ, Sch Med, Dept Dermatol, Tokyo, Japan

[3] Natl Cardiovasc Ctr, Res Inst, Dept Biochem, Osaka, Japan

[4] Keio Univ, Sch Med, Ctr Integrated Med Res, Tokyo, Japan

来源：

FEBS LETTERS | 2003年 / 541卷 / 1-3期

基金：

日本学术振兴会;

关键词：

preproghrelin; ghrelin; diabetes; stomach; growth hormone;

D O I：

10.1016/S0014-5793(03)00306-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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收藏

页码：64 / 68

页数：5

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