Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2

被引：60

作者：

Tellier, F

Acher, F

Brabet, I

Pin, JP

Azerad, R

机构：

[1] Univ Paris 05, CNRS, URA 400, Chim & Biochim Pharmacol & Toxicol Lab, F-75270 Paris 06, France

[2] CNRS, INSERM, Ctr Pharmacol Endocrinol, UPR 9023, F-34094 Montpellier 05, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 02期

关键词：

norbornane analog; aminocyclopentane-1,3-dicarboxylic acid (ACPD); glutamic acid; conformation; metabotropic receptors;

D O I：

10.1016/S0968-0896(97)10031-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isomeric norbornane-derived rigid analogs mimicking different potential conformations of ACPD (1-aminocyclopentane-1,3-dicarboxylic acid) and glutamic acid have been synthesized, via the hydantoin route, to be used as conformational probes for bioactive conformations at the glutamatergic receptors of the central nervous system. Activities on metabotropic receptors mGluR1 and mGluR2 are reported and discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：195 / 208

页数：14

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