Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity

被引：98

作者：

Choubey, Divaker ^{[1
,2
]}

Duan, Xin ^{[1
]}

Dickerson, Eric ^{[1
]}

Ponomareva, Larissa ^{[1
,2
]}

Panchanathan, Ravichandran ^{[1
,2
]}

Shen, Hui ^{[1
,2
]}

Srivastava, Ratika ^{[1
]}

机构：

[1] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA

[2] Cincinnati VA Med Ctr, Res Serv, Cincinnati, OH USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2010年 / 30卷 / 06期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; TUMOR-SUPPRESSOR PROTEIN; LUPUS-LIKE DISEASE; I-INTERFERON; INNATE IMMUNITY; HIN-200; FAMILY; P202; PROTEIN; BINDING-PROPERTIES; ADAPTIVE IMMUNITY; ACTIVATABLE GENE;

D O I：

10.1089/jir.2009.0096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deregulated innate immune responses that result in increased levels of type I interferons (IFNs) and stimulation of IFN-inducible genes are thought to contribute to chronic inflammation and autoimmunity. One family of IFN-inducible genes is the Ifi200 family, which includes the murine (eg, Ifi202a, Ifi202b, Ifi203, Ifi204, Mndal, and Aim2) and human (eg, IFI16, MNDA, IFIX, and AIM2) genes. Genes in the family encode structurally related proteins (the p200-family proteins), which share at least one partially conserved repeat of 200-amino acid (200-AA) residues. Consistent with the presence of 2 consecutive oligonucleotide/oligosaccharide-binding folds in the repeat, the p200-family proteins can bind to DNA. Additionally, these proteins (except the p202 proteins) also contain a pyrin (PYD) domain in the N-terminus. Increased expression of p202 proteins in certain strains of female mice is associated with lupus-like disease. Interestingly, only the Aim2 protein is conserved between the mouse and humans. Several recent studies have provided evidence that the Aim2 and p202 proteins can recognize DNA in cytoplasm and the Aim2 protein upon sensing DNA can form a caspase-1-activating inflammasome. In this review, we discuss how the ability of p200-family proteins to sense cytoplasmic DNA may contribute to the development of chronic inflammation and associated diseases.

引用

页码：371 / 380

页数：10

共 83 条

[11] An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome [J].

Buerckstuemmer, Tilmann ;

Baumann, Christoph ;

Blueml, Stephan ;

Dixit, Evelyn ;

Duernberger, Gerhard ;

Jahn, Hannah ;

Planyavsky, Melanie ;

Bilban, Martin ;

Colinge, Jacques ;

Bennett, Keiryn L. ;

Superti-Furga, Giulio .

NATURE IMMUNOLOGY, 2009, 10 (03) :266-272

[12] Special issue: Emerging multiple access technologies [J].

Chen, HH ;

Li, DB ;

Bi, Q .

WIRELESS COMMUNICATIONS & MOBILE COMPUTING, 2005, 5 (01) :1-4

[13] Comment on:: The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function [J].

Choubey, D. .

RHEUMATOLOGY, 2008, 47 (04) :558-559

[14] Subcellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon-inducible candidate for lupus susceptibility [J].

Choubey, D ;

Pramanik, R ;

Xin, H .

FEBS LETTERS, 2003, 553 (03) :245-249

[15] INTERFERON ACTION - CYTOPLASMIC AND NUCLEAR-LOCALIZATION OF THE INTERFERON-INDUCIBLE 52-KD PROTEIN THAT IS ENCODED BY THE IFI 202 GENE FROM THE GENE 200 CLUSTER [J].

CHOUBEY, D ;

LENGYEL, P .

JOURNAL OF INTERFERON RESEARCH, 1993, 13 (01) :43-52

[16] Interferon-inducible P202 in the susceptibility to systemic lupus [J].

Choubey, D ;

Kotzin, BL .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2002, 7 :E252-E262

[17] Cytoplasmic localization of the interferon-inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200-gene family [J].

Choubey, D ;

Walter, S ;

Geng, YB ;

Xin, H .

FEBS LETTERS, 2000, 474 (01) :38-42

[18] The interferon-inducible growth-inhibitory p202 protein: DNA binding properties and identification of a DNA binding domain [J].

Choubey, D ;

Gutterman, JU .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 221 (02) :396-401

[19]

Choubey D, 2000, J BIOL REG HOMEOS AG, V14, P187

[20] Interferon-inducible Ifi200-family genes in systemic lupus erythematosus [J].

Choubey, Divaker ;

Panchanathan, Ravichandran .

IMMUNOLOGY LETTERS, 2008, 119 (1-2) :32-41

← 1 2 3 4 5 6 7 8 9 →