Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody

被引:56
作者
Barajas, Ramon F. [3 ]
Collins, D. Eric [2 ]
Cha, Soonmee [3 ]
Geschwind, Michael D. [1 ]
机构
[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
[2] Associated Neurol Med Grp Inc, Oakland, CA USA
[3] Univ Calif San Francisco, Dept Radiol, Neuroradiol Sect, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
Anti-VGKC antibody; Seizure disorder; Limbic encephalitis; Encephalopathy; LIMBIC ENCEPHALITIS; AUTOIMMUNITY; VARIANTS; EPILEPSY;
D O I
10.1111/j.1528-1167.2009.02287.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
P>Voltage-gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that autoantibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new-onset drug-refractory seizure disorder associated with the presence of high levels of serum anti-voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti-voltage-gated potassium channel antibody associated drug-refractory seizure disorder, although rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.
引用
收藏
页码:473 / 477
页数:5
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