Noncoding RNA transcription beyond annotated genes

被引：98

作者：

Carninci, Piero

Hayashizaki, Yoshihide

机构：

[1] RIKEN, Yokohama Inst, Genom Sci Ctr,Tsurumi Ku, Genome Explorat Res Grp,Genome Network Project Co, Yokohama, Kanagawa 2300045, Japan

[2] RIKEN, Wako Inst, Genome Sci Lab, Discovery & Res Inst, Wako, Saitama 3510198, Japan

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2007年 / 17卷 / 02期

关键词：

D O I：

10.1016/j.gde.2007.02.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent analyses based on high-throughput transcriptome data have revealed that the fraction of the genome that is transcribed largely exceeds the fraction encoding protein. Transcription of unconventional genes into noncoding RNAs is widespread and, in mammals, these RNAs comprise at least half the total number of RNAs transcribed by RNA polymerase II. Although the function of the majority of noncoding RNAs has yet to be discovered, many of them are transcribed from both strands of the genome, and evidence points towards a regulatory function for many noncoding RNAs in mammalian cells.

引用

页码：139 / 144

页数：6

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