Cytotoxic Coumarins from the root of Angelica dahurica

被引：66

作者：

Thanh, PN

Jin, WY

Song, GY

Bae, KH ^{[1
]}

Kang, SS

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 12期

关键词：

Angelica dahurica; coumarins; pangelin; oxypeucedanin hydrate acetonide; tumor cells; cytotoxicity;

D O I：

10.1007/BF02975883

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten coumarins were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, oxypeucedanin hydrate acetonide (7) was isolated for the first time from this plant. Cytotoxicity of coumarins isolated were determined in vitro against L1210, HL-60, K562, and B16F10 tumor cell lines by MTT method. Pangelin (5) and oxypeucedanin hydrate acetonide (7) showed a potent cytotoxic activity with the IC50 values of 8.6 to 14.6 mug/mL against four kinds of tumor cell lines. Other compounds showed the moderate cytotoxic activity or no activity against the tumor cell lines.

引用

页码：1211 / 1215

页数：5

共 22 条

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