Inhibitory effect of serotonin on feeding behavior in goldfish: Involvement of CRF

被引：151

作者：

De Pedro, N ^{[1
]}

Pinillos, ML ^{[1
]}

Valenciano, AI ^{[1
]}

Alonso-Bedate, M ^{[1
]}

Delgado, MJ ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Ciencias Biol, Dept Biol Anim Fisiol Anim 2, E-28040 Madrid, Spain

来源：

PEPTIDES | 1998年 / 19卷 / 03期

关键词：

goldfish; serotonin; CRF; food intake; alpha-helical; CRF[9-41; intracerebroventricular; antagonism; feeding behavior;

D O I：

10.1016/S0196-9781(97)00469-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible action of 5-HT on feeding behavior in goldfish has been studied. Food intake was significantly reduced by intracerebroventricular (ICV) injection of serotonin (5-HT, 10 mu g) at 2 h postinjection. After peripheral (intraperitoneal) administration of 5-HT (1 and 10 mu g/g bw), no significant modifications in food intake were detected. Thus, it can be concluded that there is a central anoretic action of 5-HT in teleost fish. Taking in mind the inhibitory effect of corticotropin releasing factor (CRF) on feeding in teleosts and the interactions between 5-HT and CRF described in mammals, we investigated the possible involvement of CRF as mediator of the 5-HT anoretic action in goldfish. The ICV pretreatment with alpha-Helical CRF[9-41] (20 mu g) partially blocked the inhibitory effect of 5-HT on food consumption in goldfish. These results show that CRF mediates, at least in part, the 5-HT-induced feeding inhibition in goldfish. On the other hand, the alterations in hypothalamic indoleamines content evoked by ICV treatments would suggest that the activation of CRF neurons by 5-HT appears to inhibit hypothalamic serotoninergic transmission, supporting the intermediate role of this neuropeptide in the central anoretic effect of 5-HT in goldfish. (C) 1998 Elsevier Science Inc.

引用

页码：505 / 511

页数：7

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