Dimeric inhibin serum values as markers of ovarian activity in pill-free intervals

被引：9

作者：

Renier, MA

Vereecken, A

Van Herck, E

Straetmans, D

Ramaekers, P

Vanderheyden, J

Degezelle, H

Buytaert, P

机构：

[1] Univ Antwerp Hosp, Dept Obstet & Gynecol, B-2650 Edegem, Belgium

[2] Clin Pathol Lab, Antwerp, Belgium

来源：

CONTRACEPTION | 1998年 / 57卷 / 01期

关键词：

inhibin B; inhibin A; pill-free interval; ovarian activity;

D O I：

10.1016/S0010-7824(97)00206-0

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Levels of inhibin A and B as well as other hormones in serum samples obtained during the pill-free interval in women taking combined oral contraceptives (OC) were measured to asses the extent of ovarian activity during that period. Type of pill and day of pill-free interval were recorded during routine gynecologic check-ups, if patients were in the pill-free period and had taken their pills regularly in the previous cycle, rn addition to inhibin A and B, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E-2), and progesterone were also quantified. Inhibin B levels rise significantly in parallel with rising levels of FSH, LH, and E-2. Progesterone levels were completely suppressed and inhibin A levels rose slightly but insignificantly. Inhibins are sensitive biochemical markers of ovarian activity in pill-free intervals. (C) 1998 Elsevier Science Inc. All rights reserved.

引用

收藏

页码：45 / 48

页数：4

相关论文

共 10 条

[1] CONSENSUS PAPER - LOW-DOSE CONTRACEPTIVE FORMULATIONS - IS FURTHER REDUCTION IN STEROID DOSAGE JUSTIFIED [J].

ELSTEIN, M .

ADVANCES IN CONTRACEPTION, 1994, 10 (01) :1-4

[2] EFFECTS OF A LOW-ESTROGEN ORAL-CONTRACEPTIVE ON URINARY-EXCRETION OF LUTEINIZING-HORMONE AND OVARIAN STEROIDS [J].

ELSTEIN, M ;

BRISTON, PG ;

JENKINS, M ;

KIRK, D ;

MILLER, H .

BRITISH MEDICAL JOURNAL, 1974, 1 (5896) :11-13

[3] Measurement of dimeric inhibin B throughout the human menstrual cycle [J].

Groome, NP ;

Illingworth, PJ ;

OBrien, M ;

Pai, R ;

Rodger, FE ;

Mather, JP ;

McNeilly, AS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (04) :1401-1405

[4] LONGITUDINAL ULTRASONOGRAPHIC STUDY OF THE OVARIAN SUPPRESSIVE ACTIVITY OF A LOW-DOSE TRIPHASIC ORAL-CONTRACEPTIVE DURING CORRECT AND INCORRECT PILL INTAKE [J].

HAMILTON, CJCM ;

HOOGLAND, HJ .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 161 (05) :1159-1162

[5]

KILLICK S, 1987, FERTIL STERIL, V48, P409

[6]

KILLICK S R, 1990, Advances in Contraception, V6, P33, DOI 10.1007/BF01849485

[7] Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: A study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles [J].

Klein, NA ;

Illingworth, PJ ;

Groome, NP ;

McNeilly, AS ;

Battaglia, DE ;

Soules, MR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (07) :2742-2745

[8] STUDIES ON LOW-DOSE ORAL-CONTRACEPTIVES - PLASMA-HORMONE CHANGES IN RELATION TO DELIBERATE PILL (MICROGYNON-30) OMISSION [J].

MORRIS, SE ;

GROOM, GV ;

CAMERON, ED ;

BUCKINGHAM, MS ;

EVERITT, JM ;

ELSTEIN, M .

CONTRACEPTION, 1979, 20 (01) :61-69

[9] RECOMBINANT HUMAN FOLLICLE-STIMULATING-HORMONE AND OVARIAN RESPONSE IN GONADOTROPIN-DEFICIENT WOMEN [J].

SCHOOT, DC ;

HARLIN, J ;

SHOHAM, Z ;

MANNAERTS, BMJL ;

LAHLOU, N ;

BOUCHARD, P ;

BENNINK, HJTC ;

FAUSER, BCJM .

HUMAN REPRODUCTION, 1994, 9 (07) :1237-1242

[10] ULTRASOUND DEMONSTRATION OF INCREASED FREQUENCY OF FUNCTIONAL OVARIAN CYSTS IN WOMEN USING PROGESTOGEN-ONLY ORAL CONTRACEPTION [J].

TAYOB, Y ;

ADAMS, J ;

JACOBS, HS ;

GUILLEBAUD, J .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1985, 92 (10) :1003-1009