Structure of a CBS-domain pair from the regulatory γ1 subunit of human AMPK in complex with AMP and ZMP

被引：76

作者：

Day, Philip

Sharff, Andrew

Parra, Lina

Cleasby, Anne

Williams, Mark

Hoerer, Stefan

Nar, Herbert

Redemann, Norbert

Tickle, Ian

Yon, Jeff

机构：

[1] Astex Therapeut Ltd, Cambridge CB4 0QA, England

[2] Boehringer Ingelheim Pharma GmbH & Co KG, D-88397 Biberach, Germany

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2007年 / 63卷

关键词：

D O I：

10.1107/S0907444907009110

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK yl in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.

引用

页码：587 / 596

页数：10

共 54 条

[1] Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site
Adams, J
Chen, ZP
Van Denderen, BJW
Morton, CJ
Parker, MW
Witters, LA
Stapleton, D
Kemp, BE
[J]. PROTEIN SCIENCE, 2004, 13 (01) : 155 - 165
[2] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY
BAILEY, S
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 : 760 - 763
[3] The structure of a domain common to archaebacteria and the homocystinuria disease protein
Bateman, A
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (01) : 12 - 13
[4] Effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats
Bergeron, R
Previs, SF
Cline, GW
Perret, P
Russell, RR
Young, LH
Shulman, GI
[J]. DIABETES, 2001, 50 (05) : 1076 - 1082
[5] Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy:: evidence for the central role of energy compromise in disease pathogenesis
Blair, E
Redwood, C
Ashrafian, H
Oliveira, M
Broxholme, J
Kerr, B
Salmon, A
Östman-Smith, I
Watkins, H
[J]. HUMAN MOLECULAR GENETICS, 2001, 10 (11) : 1215 - 1220
[6] Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa
Bowne, SJ
Sullivan, LS
Blanton, SH
Cepko, CL
Blackshaw, S
Birch, DG
Hughbanks-Wheaton, D
Heckenlively, JR
Daiger, SP
[J]. HUMAN MOLECULAR GENETICS, 2002, 11 (05) : 559 - 568
[7] Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
Buhl, ES
Jessen, N
Pold, R
Ledet, T
Flyvbjerg, A
Pedersen, SB
Pedersen, O
Schmitz, O
Lund, S
[J]. DIABETES, 2002, 51 (07) : 2199 - 2206
[8] Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the γ2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency
Burwinkel, B
Scott, JW
Bührer, C
van Landeghem, FKH
Cox, GF
Wilson, CJ
Hardie, DG
Kilimann, MW
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (06) : 1034 - 1049
[9] Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
Cheung, PCF
Salt, IP
Davies, SP
Hardie, DG
Carling, D
[J]. BIOCHEMICAL JOURNAL, 2000, 346 : 659 - 669
[10] REGULATION OF HMG-COA REDUCTASE - IDENTIFICATION OF THE SITE PHOSPHORYLATED BY THE AMP-ACTIVATED PROTEIN-KINASE INVITRO AND IN INTACT RAT-LIVER
CLARKE, PR
HARDIE, DG
[J]. EMBO JOURNAL, 1990, 9 (08) : 2439 - 2446

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