New tools to build synthetic hormonal pathways

被引：5

作者：

Conklin, Bruce R.

机构：

[1] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Pharmacol, San Francisco, CA 94143 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 12期

关键词：

D O I：

10.1073/pnas.0700913104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：4777 / 4778

页数：2

共 15 条

[1] Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand [J].

Armbruster, Blaine N. ;

Li, Xiang ;

Pausch, Mark H. ;

Herlitze, Stefan ;

Roth, Bryan L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5163-5168

[2] AGq/11-coupled mutant histamine H1 receptor F435A activated solely by synthetic ligands (RASSL) [J].

Bruysters, M ;

Jongejan, A ;

Akdemir, A ;

Bakker, RA ;

Leurs, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (41) :34741-34746

[3] A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL) [J].

Claeysen, S ;

Joubert, L ;

Sebben, M ;

Bockaert, J ;

Dumuis, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (02) :699-702

[4] Controlling signaling with a specifically designed Gi-coupled receptor [J].

Coward, P ;

Wada, HG ;

Falk, MS ;

Chan, SDH ;

Meng, F ;

Akil, H ;

Conklin, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :352-357

[5] Receptor for motilin identified in the human gastrointestinal system [J].

Feighner, SD ;

Tan, CP ;

McKee, KK ;

Palyha, OC ;

Hreniuk, DL ;

Pong, SS ;

Austin, CP ;

Figueroa, D ;

MacNeil, D ;

Cascieri, MA ;

Nargund, R ;

Bakshi, R ;

Abramovitz, M ;

Stocco, R ;

Kargman, S ;

O'Neill, G ;

Van der Ploeg, LHT ;

Evans, J ;

Patchett, AA ;

Smith, RG ;

Howard, AD .

SCIENCE, 1999, 284 (5423) :2184-2188

[6] TRANSCRIPTIONAL ACTIVATION BY TETRACYCLINES IN MAMMALIAN-CELLS [J].

GOSSEN, M ;

FREUNDLIEB, S ;

BENDER, G ;

MULLER, G ;

HILLEN, W ;

BUJARD, H .

SCIENCE, 1995, 268 (5218) :1766-1769

[7] The receptors and coding logic for bitter taste [J].

Mueller, KL ;

Hoon, MA ;

Erlenbach, I ;

Chandrashekar, J ;

Zuker, CS ;

Ryba, NJP .

NATURE, 2005, 434 (7030) :225-229

[8] Unravelling multiple ligand-activation binding sites using RASSL receptors [J].

Pauwels, PJ .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (10) :504-507

[9] Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice [J].

Redfern, CH ;

Coward, P ;

Degtyarev, MY ;

Lee, EK ;

Kwa, AT ;

Hennighausen, L ;

Bujard, H ;

Fishman, GI ;

Conklin, BR .

NATURE BIOTECHNOLOGY, 1999, 17 (02) :165-169

[10] Engineering receptors activated solely by synthetic ligands (RASSLs) [J].

Scearce-Levie, K ;

Coward, P ;

Redfern, CH ;

Conklin, BR .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (08) :414-420

← 1 2 →