Hallmarks of cancer: Interactions with the tumor stroma

被引：860

作者：

Pietras, Kristian ^{[1
]}

Ostman, Arne ^{[2
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Vasc Biol, SE-17177 Stockholm, Sweden

[2] Karolinska Univ Sjukhuset, Karolinska Inst, Dept Oncol Pathol, SE-17176 Stockholm, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 08期

基金：

瑞典研究理事会;

关键词：

Cancer; Tumor stroma; Cancer-associated fibroblast; Pericyte; Targeted therapy; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR; BREAST-CANCER; PERIVASCULAR NICHE; PANCREATIC-CANCER; MOUSE MODEL; IN-VIVO; FIBROBLASTS; PDGF; ANGIOGENESIS;

D O I：

10.1016/j.yexcr.2010.02.045

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ten years ago, Hanahan and Weinberg delineated six "Hallmarks of cancer" which summarize several decades of intense cancer research. However, tumor cells do not act in isolation, but rather subsist in a rich microenvironment provided by resident fibroblasts, endothelial cells, pericytes, leukocytes, and extra-cellular matrix. It is increasingly appreciated that the tumor stroma is an integral part of cancer initiation, growth and progression. The stromal elements of tumors hold prognostic, as well as response-predictive, information, and abundant targeting opportunities within the tumor microenvironment are continually identified. Herein we review the current understanding of tumor cell interactions with the tumor stroma with a particular focus on cancer-associated fibroblasts and pericytes. Moreover, we discuss emerging fields of research which need to be further explored in order to fulfil the promise of stroma-targeted therapies for cancer. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1324 / 1331

页数：8

共 72 条

[1] Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2 [J].

Abe, Yoshinori ;

Oda-Sato, Eri ;

Tobiume, Kei ;

Kawauchi, Keiko ;

Taya, Yoichi ;

Okamoto, Koji ;

Oren, Moshe ;

Tanaka, Nobuyuki .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) :4838-4843

[2] Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors [J].

Abramsson, A ;

Lindblom, P ;

Betsholtz, C .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (08) :1142-1151

[3] Host prostaglandin E2-EP3 signaling regulates tumor-associated angiogenesis and tumor growth [J].

Amano, H ;

Hayashi, J ;

Endo, H ;

Kitasato, H ;

Yamashina, S ;

Maruyama, T ;

Kobayashi, M ;

Satoh, K ;

Narita, M ;

Sugimoto, Y ;

Murata, T ;

Yoshimura, H ;

Narumiya, S ;

Majima, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :221-232

[4] On the origin of cancer-associated fibroblasts [J].

Anderberg, Charlotte ;

Pietras, Kristian .

CELL CYCLE, 2009, 8 (10) :1461-1462

[5] Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts [J].

Anderberg, Charlotte ;

Li, Hong ;

Fredriksson, Linda ;

Andrae, Johanna ;

Betsholtz, Christer ;

Li, Xuri ;

Eriksson, Ulf ;

Pietras, Kristian .

CANCER RESEARCH, 2009, 69 (01) :369-378

[6] CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth [J].

Augsten, Martin ;

Hagglof, Christina ;

Olsson, Eleonor ;

Stolz, Claudia ;

Tsagozis, Panagiotis ;

Levchenko, Tetyana ;

Frederick, Mitchell J. ;

Borg, Ake ;

Micke, Patrick ;

Egevad, Lars ;

Ostman, Arne .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3414-3419

[7] Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity [J].

Balsamo, Mirna ;

Scordamaglia, Francesca ;

Pietra, Gabriella ;

Manzini, Claudia ;

Cantoni, Claudia ;

Boitano, Monica ;

Queirolo, Paola ;

Vermi, William ;

Facchetti, Fabio ;

Moretta, Alessandro ;

Moretta, Lorenzo ;

Mingari, Maria Cristina ;

Vitale, Massimo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (49) :20847-20852

[8] Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors [J].

Bergers, G ;

Song, S ;

Meyer-Morse, N ;

Bergsland, E ;

Hanahan, D .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (09) :1287-1295

[9] Modes of resistance to anti-angiogenic therapy [J].

Bergers, Gabriele ;

Hanahan, Douglas .

NATURE REVIEWS CANCER, 2008, 8 (08) :592-603

[10] Stromal fibroblasts in cancer initiation and progression [J].

Bhowmick, NA ;

Neilson, EG ;

Moses, HL .

NATURE, 2004, 432 (7015) :332-337

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