Adherence to and penetration of human intestinal Caco-2 epithelial cell monolayers by Pseudomonas aeruginosa

被引：36

作者：

Hirakata, Y

Izumikawa, K

Yamaguchi, T

Igimi, S

Furuya, N

Maesaki, S

Tomono, K

Yamada, Y

Kohno, S

Yamaguchi, K

Kamihira, S

机构：

[1] Nagasaki Univ, Sch Med, Dept Lab Med, Nagasaki 852, Japan

[2] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 852, Japan

[3] Natl Ctr Infect Dis, Dept Biomed Food Res, Tokyo 162, Japan

[4] Toho Univ, Sch Med, Dept Microbiol, Tokyo 143, Japan

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 04期

关键词：

D O I：

10.1128/IAI.66.4.1748-1751.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical isolates of Pseudomonas aeruginosa from blood adhered to and penetrated intestinal Caco-2 cell monolayers to a greater degree than did isolates from sputum, with a concomitant drastic decrease in transepithelial electrical resistance. PAO-PR1, an avirulent exotoxin A mutant of PAO1, did not cause a decrease in the resistance. The Caco-2 monolayer system may be useful for the evaluation of certain P. aeruginosa virulence factor activities.

引用

页码：1748 / 1751

页数：4

共 26 条

[1]

BRYAN CS, 1983, REV INFECT DIS, V5, P629

[2] ISOLATION AND CHARACTERIZATION OF A PSEUDOMONAS-AERUGINOSA MUTANT PRODUCING A NONTOXIC, IMMUNOLOGICALLY CROSSREACTIVE TOXIN-A PROTEIN [J].