A new structural theme in the imidazole-containing alkaloids from a calcareous Leucetta sponge

被引：64

作者：

Ralifo, P

Crews, P ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 26期

关键词：

D O I：

10.1021/jo048789+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Further study of the Fijian sponge Leucetta sp., a source of (+)-calcaridine A (4) and (-)spirocalcaridines A (5) and B (6), has yielded (-)-spiroleucettadine (8), the first natural product to contain a fused 2-aminoimidazole oxalane ring along with the known compounds NN-dimethylnaamidine D (3) and isonaamine B (7). NMR analysis allowed the unambiguous 2D structural assignment of 8, and its relative stereochemistry was determined by ROESY data. Good antibacterial activity was observed for 8 against Enterococcus durans with an MIC of less than 6.25 mug/mL.

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页码：9025 / 9029

页数：5

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