The circadian clock: Pacemaker and tumour suppressor

被引：539

作者：

Fu, LN ^{[1
]}

Lee, CC ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 05期

关键词：

D O I：

10.1038/nrc1072

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The circadian rhythms are daily oscillations in various biological processes that are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer in humans, One of the cellular processes that is regulated by circadian rhythm is cell proliferation, which often shows asynchrony between normal and malignant tissues. This asynchrony highlights the importance of the circadian clock in tumour suppression in vivo and is one of the theoretical foundations for cancer chronotherapy. Investigation of the mechanisms by which the circadian clock controls cell proliferation and other cellular functions might lead to new therapeutic targets.

引用

页码：350 / 361

页数：12

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