Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications

被引：161

作者：

Khutoryanskiy, Vitaliy V. ^{[1
]}

机构：

[1] Univ Reading, Sch Pharm, Reading RG6 6AD, Berks, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2007年 / 334卷 / 1-2期

关键词：

interpolymer complexes; mucoadhesion; solid drug dispersions; multilayered materials; nanoparticles; in situ gelling systems;

D O I：

10.1016/j.ijpharm.2007.01.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Association of poly(carboxylic acids) and non-ionic polymers in solutions via hydrogen bonding results in formation of novel polymeric materials-interpolymer complexes. These materials can potentially be used for design of novel mucoadhesive dosage forms, development of solid drug dispersions and solubilisation of poorly soluble drugs, encapsulation technologies, preparation of nanoparticles, hydrogels, in situ gelling systems and electrically erodible materials. This review is an attempt to analyse and systematise existing literature on pharmaceutical application of hydrogen-bonded interpolymer complexes. (c) 2007 Elsevier B.V All rights reserved.

引用

页码：15 / 26

页数：12

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