SPR imaging-based salivary diagnostics system for the detection of small molecule analytes

被引：34

作者：

Fu, Elain

Chinowsky, Timothy

Nelson, Kjell

Johnston, Kyle

Edwards, Thayne

Helton, Kristen

Grow, Michael

Miller, John W.

Yager, Paul

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA

[3] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[4] Univ Washington, Reg Epilepsy Ctr, Seattle, WA 98195 USA

来源：

ORAL-BASED DIAGNOSTICS | 2007年 / 1098卷

关键词：

SPR imaging; microfluidic assay; saliva; diagnostics;

D O I：

10.1196/annals.1384.026

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Saliva is an underused fluid with considerable promise for biomedical testing. Its potential is particularly great for monitoring small-molecule analytes since these are often present in saliva at concentrations that correlate well with their free levels in blood. We describe the development of a prototype diagnostic device for the rapid detection of the antiepileptic drug (AED) phenytoin in saliva. The multicomponent system includes a hand-portable surface plasmon resonance (SPR) imaging instrument and a disposable microfluidic assay card.

引用

页码：335 / 344

页数：10

共 13 条

[1] A planar microfabricated fluid [J].