An efficient one-pot synthesis of α-amino phosphonates catalyzed by bismuth nitrate pentahydrate

被引:100
作者
Bhattacharya, Asish K.
Kaur, Tanpreet
机构
[1] Natl Chem Lab, Combi Chem Bio Resource Ctr, Pune 411008, Maharashtra, India
[2] Natl Chem Lab, Div Organ Chem Synth, Pune 411008, Maharashtra, India
关键词
alpha-amino phosphonates; aldehydes; amines; alkyl phosphite; bismuth nitrate pentahydrate; synthetic methods;
D O I
10.1055/s-2007-970762
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple, efficient, and environmentally benign method has been developed for the synthesis of alpha-amino phosphonates through a one-pot reaction of aldehydes with amines and diethyl phosphite in the presence of bismuth nitrate pentahydrate as a catalyst. Some of the major advantages of this protocol are: good yields, the involvement of a less-expensive and non-toxic catalyst, mild and solvent-free reaction conditions and also tolerance towards other functional groups present in the substrates. Eighteen examples are described, highlighting the substrate scope of the reaction.
引用
收藏
页码:745 / 748
页数:4
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