Remifentanil inhibits muscular more than cutaneous pain in humans

被引：34

作者：

Curatolo, M ^{[1
]}

Petersen-Felix, S

Gerber, A

Arendt-Nielsen, L

机构：

[1] Univ Hosp Bern, Inselspital, Dept Anaesthesiol, Div Pain Therapy, CH-3010 Bern, Switzerland

[2] Univ Hosp Bern, Inselspital, Dept Anaesthesiol, Div Obstet Anaesthesia, CH-3010 Bern, Switzerland

[3] Aalborg Univ, Ctr Sensory Motor Interact, Lab Expt Pain Res, DK-9220 Aalborg, Denmark

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2000年 / 85卷 / 04期

关键词：

analgesics opioid; remifentanil; pain; experimental;

D O I：

10.1093/bja/85.4.529

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

In experimental studies, drug-induced analgesia is usually assessed by cutaneous stimulation. If analgesics act differently on cutaneous and deep nociception, the results of these studies may not be entirely applicable to clinical pain involving deep structures. We tested the hypothesis that opioids have different abilities to inhibit cutaneous and muscular pain. Either the opioid remifentanil or placebo was infused in 12 healthy volunteers in a cross-over fashion. Repeated electrical stimulation (five impulses at 2 Hz) was applied to both skin and muscle. Pain thresholds were recorded. Remifentanil caused a higher increase in the muscular pain thresholds than in the cutaneous pain thresholds (P=0.035). We conclude that opioids inhibit muscular pain more strongly than cutaneous pain in humans.

引用

页码：529 / 532

页数：4

共 19 条

[1]

Arendt-Nielsen L, 1997, PROG PAIN RES MANAG, V8, P393

[2] THE EFFECT OF N-METHYL-D-ASPARTATE ANTAGONIST (KETAMINE) ON SINGLE AND REPEATED NOCICEPTIVE STIMULI - A PLACEBO-CONTROLLED EXPERIMENTAL HUMAN STUDY [J].

ARENDTNIELSEN, L ;

PETERSENFELIX, S ;

FISCHER, M ;

BAK, P ;

BJERRING, P ;

ZBINDEN, AM .

ANESTHESIA AND ANALGESIA, 1995, 81 (01) :63-68

[3] ELECTROPHYSIOLOGICAL AND PSYCHOPHYSICAL QUANTIFICATION OF TEMPORAL SUMMATION IN THE HUMAN NOCICEPTIVE SYSTEM [J].

ARENDTNIELSEN, L ;

BRENNUM, J ;

SINDRUP, S ;

BAK, P .

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, 1994, 68 (03) :266-273

[4] Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin [J].

Babenko, V ;

Graven-Nielsen, T ;

Svensson, P ;

Drewes, AM ;

Jensen, TS ;

Arendt-Nielsen, L .

PAIN, 1999, 82 (01) :1-8

[5] Experimental human muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P [J].

Babenko, V ;

Graven-Nielsen, T ;

Svensson, P ;

Drewes, AM ;

Jensen, TS ;

Arendt-Nielsen, L .

EUROPEAN JOURNAL OF PAIN-LONDON, 1999, 3 (02) :93-102

[6] QUANTITATIVE SENSORY EXAMINATION IN HUMAN EPIDURAL-ANESTHESIA AND ANALGESIA - EFFECTS OF LIDOCAINE [J].

BRENNUM, J ;

ARENDTNIELSEN, L ;

SECHER, NH ;

JENSEN, TS ;

BJERRING, P .

PAIN, 1992, 51 (01) :27-34

[7] TEMPORAL SUMMATION DURING EXTRADURAL ANESTHESIA [J].

CURATOLO, M ;

PETERSENFELIX, S ;

ARENDTNIELSEN, L ;

FISCHER, M ;

ZBINDEN, AM .

BRITISH JOURNAL OF ANAESTHESIA, 1995, 75 (05) :634-635

[8] Adding sodium bicarbonate to lidocaine enhances the depth of epidural blockade [J].

Curatolo, M ;

Petersen-Felix, S ;

Arendt-Nielsen, L ;

Lauber, R ;

Högström, H ;

Scaramozzino, P ;

Luginbühl, M ;

Sieber, TJ ;

Zbinden, AM .

ANESTHESIA AND ANALGESIA, 1998, 86 (02) :341-347

[9] Intrathecal, but not intravenous, clonidine reduces experimental thermal or capsaicin-induced pain and hyperalgesia in normal volunteers [J].

Eisenach, JC ;

Hood, DD ;

Curry, R .

ANESTHESIA AND ANALGESIA, 1998, 87 (03) :591-596

[10] Quantification of local and referred muscle pain in humans after sequential im injections of hypertonic saline [J].

GravenNielsen, T ;

ArendtNielsen, L ;

Svensson, P ;

Jensen, TS .

PAIN, 1997, 69 (1-2) :111-117

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