The influence of body weight on open field and swimming maze performance during the post-weaning period in the rat

被引：7

作者：

Barrow, P

Leconte, I

机构：

[1] Pharmakon Europe, 69593 L'Arbresle Cedex, Les Oncins

来源：

LABORATORY ANIMALS | 1996年 / 30卷 / 01期

关键词：

rat; body weight; behaviour; open field; maze;

D O I：

10.1258/002367796780744901

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 [兽医学];

摘要：

The open field and swimming maze tests are frequently used as part of a behavioural assessment battery in reproduction or developmental toxicology studies in the rat. Interpretation of the results of these tests is very difficult when the body weight of the rats is not similar in the various treatment groups. In order to better understand this problem, data from approximately 500 untreated rats tested under identical conditions were analysed with respect to body weight. No correlation was found in water maze performance or open field motor activity. A very slight but significant correlation was identified, however, in the time spent by female rats in various regions of the open field, with the smaller rats spending more time in the corners of the testing arena.

引用

页码：22 / 27

页数：6

共 18 条

[1]

Adams J, 1981, DEV TOXICOLOGY, P233

[2]

Chow B F, 1974, Adv Exp Med Biol, V49, P183

[3]

DARCY DF, 1993, 2ND P INT C HARM ORL, P557

[4]

LONG-TERM DEFICITS IN CEREBELLAR GROWTH AND ROTAROD PERFORMANCE OF RATS FOLLOWING BINGE-LIKE ALCOHOL EXPOSURE DURING THE NEONATAL BRAIN GROWTH SPURT [J].