Impact of Long-acting Calcium Channel Blockers on the Prognosis of Patients with Coronary Artery Disease With and Without Chronic Kidney Disease: a Comparison of Three Drugs

被引：2

作者：

Nitta, Y. ^{[1
]}

Yamamoto, R. ^{[1
]}

Yamaguchi, Y. ^{[1
]}

Katsuda, S. ^{[1
]}

Kaku, B. ^{[1
]}

Taguchi, T. ^{[1
]}

Takabatake, S. ^{[2
]}

Nakahama, K. ^{[2
]}

Yamagishi, M. ^{[1
]}

机构：

[1] Toyama Red Cross Hosp, Div Cardiol, Toyama 9300859, Japan

[2] Kanazawa Univ, Div Cardiovasc Med, Grad Sch Med Sci, Kanazawa, Ishikawa, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2010年 / 38卷 / 01期

关键词：

CORONARY ARTERY DISEASE; HYPERTENSION; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CALCIUM CHANNEL BLOCKER; BENIDIPINE; AMLODIPINE; NIFEDIPINE; PROGNOSIS; RANDOMIZED CONTROLLED-TRIAL; HYPERTENSIVE PATIENTS; VASOSPASTIC ANGINA; CARDIOVASCULAR EVENTS; MYOCARDIAL-INFARCTION; TERM PROGNOSIS; ANTAGONISTS; BENIDIPINE; OUTCOMES; AMLODIPINE;

D O I：

10.1177/147323001003800130

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Calcium channel blockers(CCBs) can prevent cardiovascular events in patients with coronary artery disease (CAD). This study looked retrospectively at the prognosis of CAD in hypertensive patients with CAD who had undergone a coronary angiograph, had been given a CCB (benidipine [n = 66], amlodipine [n = 45], or long-acting nifedipine [n = 31]) on hospital discharge and were then followed up for a mean +/- SD of 5.2 +/- 2.9 years. Systolic/diastolic blood pressure for all 142 patients decreased significantly from a mean +/- SD of 137 +/- 20/74 +/- 15 mmHg to 129 +/- 20/71 +/- 12 mmHg. Major adverse cardiovascular events (MACE) occurred in 15 patients. Chronic kidney disease (CKD) was a significant risk factor for MACE (hazard ratio 2.35, 95% confidence intervals 1.45, 3.80). Benidipine was superior to nifedipine in preventing MACE in patients both with and without CKD. In conclusion, benidipine and amlodipine reduced the frequency of MACE in hypertensive patients with CAD, particularly in those with complicating CKD.

引用

页码：253 / 265

页数：13

共 24 条

[1] Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R [J].

Akizuki, Osamu ;

Inayoshi, Atsushi ;

Kitayama, Tetsuya ;

Yao, Kozo ;

Shirakura, Shiro ;

Sasaki, Katsutoshi ;

Kusaka, Hideaki ;

Matsubara, Masahiro .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 584 (2-3) :424-434

[2] Effect of long-acting and short-acting calcium antagonists on cardiovascular outcomes in hypertensive patients [J].

Alderman, MH ;

Cohen, H ;

Roque, R ;

Madhavan, S .

LANCET, 1997, 349 (9052) :594-598

[3]

Austen W G, 1975, Circulation, V51, P5

[4] Prognostic effects of benidipine in patients with vasospastic angina: Comparison with diltiazem and amlodipine [J].

Fukumoto, Yoshihiro ;

Yasuda, Satoshi ;

Ito, Akira ;

Shimokawa, Hiroaki .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2008, 51 (03) :253-257

[5]

Furberg CD, 2002, JAMA-J AM MED ASSOC, V288, P2981

[6]

Io K, 2007, ARZNEIMITTELFORSCH, V57, P573

[7] Changing characteristics of patients with vasospastic angina in the era of new calcium channel blockers [J].

Ito, A ;

Fukumoto, Y ;

Shimokawa, H .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2004, 44 (04) :480-485

[8] Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial [J].

Julius, S ;

Kjeldsen, SE ;

Weber, M ;

Brunner, HR ;

Ekman, S ;

Hansson, L ;

Hua, TS ;

Laragh, J ;

McInnes, GT ;

Mitchell, L ;

Plat, F ;

Schork, A ;

Smith, B ;

Zanchetti, A .

LANCET, 2004, 363 (9426) :2022-2031

[9]

Karasawa A, 1999, Nihon Yakurigaku Zasshi, V113, P317

[10] CALCIUM ANTAGONISTIC EFFECTS AND THE INVITRO DURATION OF ACTIONS OF KW-3049, A NEW 1,4-DIHYDROPYRIDINE DERIVATIVE, IN ISOLATED CANINE CORONARY-ARTERIES [J].

KARASAWA, A ;

KUBO, K .

JAPANESE JOURNAL OF PHARMACOLOGY, 1988, 47 (01) :35-44

← 1 2 3 →