Antiviral flavonoids from the root bark of Morus alba L.

被引：242

作者：

Du, J

He, ZD

Jiang, RW

Ye, WC

Xu, HX

But, PPH ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Biol & Chem, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China

[3] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China

来源：

PHYTOCHEMISTRY | 2003年 / 62卷 / 08期

关键词：

Morus alba; Moraceae; moralbanone; leachianone; mulberroside; flavonoid; antiviral; herpes;

D O I：

10.1016/S0031-9422(02)00753-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC50= 1.6 mug/ml), whereas mulberroside C showed weak activity (IC50=75.4 mug/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1235 / 1238

页数：4

共 29 条

[1] Phenolic constituents of Ononis vaginalis roots [J].