Correlation of apoptosis with tumour cell differentiation, progression, and HPV infection in cervical carcinoma

被引:59
作者
Shoji, Y [1 ]
Saegusa, M [1 ]
Takano, Y [1 ]
Ohbu, M [1 ]
Okayasu, I [1 ]
机构
[1] KITASATO UNIV,SCH MED,DEPT PATHOL,SAGAMIHARA,KANAGAWA 228,JAPAN
关键词
apoptosis; KPV; GIN; SCC; Ki-67;
D O I
10.1136/jcp.49.2.134
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Aims-To clarify the significance of apoptosis in the progression of uterine cervical neoplasias, including cervical intraepithelial neoplasia (CIN), microinvasive carcinoma (MIC), and invasive squamous cell carcinoma (ISCC) categories, in relation to cell proliferation and human papilloma virus (HPV) infection. Methods-Forty six cases of CIN I/II, 75 of ClN I/II, 16 of MIC, and 44 of ISCC were examined using formalin fixed and paraffin wax embedded samples. The TdT mediated dUTP-biotin nick end labelling (TUNEL) method for detection of apoptotic cells was performed along with Ki-67 immunohistochemistry. Presence of HPV-DNA was confirmed by PCR-RFLP assay. Results-Apoptotic labelling indices, calculated after counting positive nuclei among at least 2000 nuclei, showed significant positive correlation with histological malignant grading in CIN and tumour cell invasion into stroma. In contrast, similar Ki-67 labelling index values were found in GIN, MIG, and ISCC. Although HPV-DNA was detected in 35/46 CIN I/II (76.1%), 53/74CIN III (71.6%), 9/ 16 MIC (56.3%), and 36/44 ISCC (81.8%), there was no apparent relation with the apoptotic labelling indices. Conclusions-Apoptosis in cervical neoplasias may be closely related to tumour cell differentiation and progression. It also seems unlikely that HPV itself is directly related to pathways regulating apoptosis.
引用
收藏
页码:134 / 138
页数:5
相关论文
共 35 条
[1]   FREQUENCY OF APOPTOTIC BODIES POSITIVELY CORRELATES WITH GLEASON GRADE IN PROSTATE-CANCER [J].
AIHARA, M ;
TRUONG, LD ;
DUNN, JK ;
WHEELER, TM ;
SCARDINO, PT ;
THOMPSON, TC .
HUMAN PATHOLOGY, 1994, 25 (08) :797-801
[2]   ROLE OF APOPTOSIS IN MODULATION OF THE GROWTH OF HUMAN COLORECTAL TUBULAR AND VILLOUS ADENOMAS [J].
ARAI, T ;
KINO, I .
JOURNAL OF PATHOLOGY, 1995, 176 (01) :37-44
[3]   PREVALENCE OF HUMAN PAPILLOMAVIRUS IN CERVICAL-CANCER - A WORLDWIDE PERSPECTIVE [J].
BOSCH, FX ;
MANOS, MM ;
MUNOZ, N ;
SHERMAN, M ;
JANSEN, AM ;
PETO, J ;
SCHIFFMAN, MH ;
MORENO, V ;
KURMAN, R ;
SHAH, KV ;
ALIHONOU, E ;
BAYO, S ;
MOKHTAR, HC ;
CHICAREON, S ;
DAUDT, A ;
DELOSRIOS, E ;
GHADIRIAN, P ;
KITINYA, JN ;
KOULIBALY, M ;
NGELANGEL, C ;
TINTORE, LMP ;
RIOSDALENZ, JL ;
SARJADI ;
SCHNEIDER, A ;
TAFUR, L ;
TEYSSIE, AR ;
ROLON, PA ;
TORROELLA, M ;
TAPIA, AV ;
WABINGA, HR ;
ZATONSKI, W ;
SYLLA, B ;
VIZCAINO, P ;
MAGNIN, D ;
KALDOR, J ;
GREER, C ;
WHEELER, C .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (11) :796-802
[4]   THE ROLE OF HUMAN PAPILLOMAVIRUSES IN THE PATHOGENESIS AND HISTOLOGIC CLASSIFICATION OF PRECANCEROUS LESIONS OF THE CERVIX [J].
BRESCIA, RJ ;
JENSON, AB ;
LANCASTER, WD ;
KURMAN, RJ .
HUMAN PATHOLOGY, 1986, 17 (06) :552-559
[5]   REQUIREMENT FOR A FUNCTIONAL RB-1 GENE IN MURINE DEVELOPMENT [J].
CLARKE, AR ;
MAANDAG, ER ;
VANROON, M ;
VANDERLUGT, NMT ;
VANDERVALK, M ;
HOOPER, ML ;
BERNS, A ;
RIELE, HT .
NATURE, 1992, 359 (6393) :328-330
[6]   THYMOCYTE APOPTOSIS INDUCED BY P53-DEPENDENT AND INDEPENDENT PATHWAYS [J].
CLARKE, AR ;
PURDIE, CA ;
HARRISON, DJ ;
MORRIS, RG ;
BIRD, CC ;
HOOPER, ML ;
WYLLIE, AH .
NATURE, 1993, 362 (6423) :849-852
[7]   SIMPLIFIED PROCEDURES FOR APPLYING THE POLYMERASE CHAIN-REACTION TO ROUTINELY FIXED PARAFFIN WAX SECTIONS [J].
COATES, PJ ;
DARDENNE, AJ ;
KHAN, G ;
KANGRO, HO ;
SLAVIN, G .
JOURNAL OF CLINICAL PATHOLOGY, 1991, 44 (02) :115-118
[8]   C-MYC PROTEIN AND KI-67 ANTIGEN IMMUNODETECTION IN PATIENTS WITH UTERINE CERVIX NEOPLASIA - CORRELATION OF MICROCYTOPHOTOMETRIC ANALYSIS AND HISTOLOGICAL DATA [J].
DEVICTOR, B ;
BONNIER, P ;
PIANA, L ;
ANDRAC, L ;
LAVAUT, MN ;
ALLASIA, C ;
CHARPIN, C .
GYNECOLOGIC ONCOLOGY, 1993, 49 (03) :284-290
[9]   THE HUMAN PAPILLOMA VIRUS-16 E7-ONCOPROTEIN IS ABLE TO BIND TO THE RETINOBLASTOMA GENE-PRODUCT [J].
DYSON, N ;
HOWLEY, PM ;
MUNGER, K ;
HARLOW, E .
SCIENCE, 1989, 243 (4893) :934-937
[10]  
EHRMANN RL, 1994, BENIGN MALIGNANT PRO, P116