Studies towards the total synthesis of an epoxy isoprostane phospholipid, a potent activator of endothelial cells

被引：11

作者：

Jung, ME

Kers, A

Subbanagounder, G

Berliner, JA

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 02期

关键词：

D O I：

10.1039/b209892j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report studies toward the total synthesis of an epoxy isoprostane, namely the preparation of compound 9 which is an analogue of the elimination product 7 of the naturally occurring epoxy isoprostane 4 by a straightforward route using a three-component coupling, and have shown by several spectroscopic criteria that it closely resembles the natural material.

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页码：196 / 197

页数：2

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