Ultrastructural analyses of β-amyloid in the aged dog brain:: Neuronal β-amyloid is localized to the plasma membrane

被引：30

作者：

Torp, R

Head, E

Cotman, CW

机构：

[1] Univ Oslo, Inst Basic Med Sci, Dept Anat, N-0317 Oslo, Norway

[2] Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2000年 / 24卷 / 05期

关键词：

beta-amyloid; electron microscopy; immunocytochemistry; neuropathology;

D O I：

10.1016/S0278-5846(00)00107-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. An electron microscopic study was undertaken to study beta-amyloid (A beta) deposition and neuropathology in aged dogs. 2. A positive correlation between A beta deposits and neuropathology was found in some dogs. Massive A beta deposition was correlated to advanced lesions. 3. By use of immunocytochemistry A beta fibers were identified within plaques, around vessels and in association with cell membranes.

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收藏

页码：801 / 810

页数：10

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