Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women's Contraceptive and Reproductive Experiences Study

被引:69
作者
Burkman, RT
Tang, MTC
Malone, KE
Marchbanks, PA
McDonald, JA
Folger, SG
机构
[1] NCI, Surveillance Epidemiol & End Results Registries, Atlanta, GA USA
[2] NCI, Surveillance Epidemiol & End Results Registries, Detroit, MI USA
[3] NCI, Surveillance Epidemiol & End Results Registries, Los Angeles, CA USA
[4] NCI, Surveillance Epidemiol & End Results Registries, Seattle, WA USA
[5] Univ Penn, Philadelphia, PA 19104 USA
[6] Ctr Dis Control & Prevent, Atlanta, GA USA
[7] NICHHD, Bethesda, MD 20892 USA
关键词
breast cancer; infertility; infertility drugs; human menopausal gonadotropins (hMG);
D O I
10.1016/S0015-0282(02)04950-6
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine the association between infertility drug use and invasive breast cancer in a population-based case-control study. Design: Multicenter case-control study. Setting: Women aged 35 to 64 years in metropolitan Atlanta, Detroit, Los Angeles, Philadelphia, and Seattle. Patient(s): The 4,575 case patients had histologically confirmed primary invasive breast cancer. The 4,682 control subjects were women without breast cancer identified in the same geographic locations using randomized-digit dialing. Intervention(s): A standardized questionnaire focusing on reproductive health and family history as well as use of oral contraceptives and other hormones and infertility drugs was administered to all subjects. Data on the type of breast cancer were also obtained. Main Outcome Measure(s): Odds ratios examining the association between use of various infertility drugs and invasive breast cancer. Result(s): Overall, a history of infertility drug use was not associated with the risk of developing breast cancer. Compared with women who never used any fertility medication, however, women using human menopausal gonadotropin (hMG) for greater than or equal to6 months or for at least six cycles had a relative risk of breast cancer ranging between 2.7 to 3.8. Conclusion(s): Long-term use of certain infertility drugs could adversely affect risk of breast cancer. Additional confirmatory studies are needed. (C) 2003 by American Society for Reproductive Medicine.
引用
收藏
页码:844 / 851
页数:8
相关论文
共 25 条
[1]  
Beral V, 1997, LANCET, V350, P1047, DOI 10.1016/S0140-6736(97)08233-0
[2]   Fertility treatment and risk of breast cancer [J].
Braga, C ;
Negri, E ;
LaVecchia, C ;
Parazzini, F ;
DalMaso, L ;
Franceschi, S .
HUMAN REPRODUCTION, 1996, 11 (02) :300-303
[3]  
BRESLOW NE, 1980, IARC SCI PUBL, V32, P325
[4]   OVARIAN STIMULATION AND BREAST-CANCER - IS THERE A LINK [J].
BRZEZINSKI, A ;
PERETZ, T ;
MORYOSEF, S ;
SCHENKER, JG .
GYNECOLOGIC ONCOLOGY, 1994, 52 (03) :292-295
[5]  
Calle EE, 1996, CONTRACEPTION, V54, pS1
[6]   INFLUENCES OF PERCUTANEOUS ADMINISTRATION OF ESTRADIOL AND PROGESTERONE ON HUMAN BREAST EPITHELIAL-CELL CYCLE IN-VIVO [J].
CHANG, KJ ;
LEE, TTY ;
LINARESCRUZ, G ;
FOURNIER, S ;
DELIGNIERES, B .
FERTILITY AND STERILITY, 1995, 63 (04) :785-791
[7]  
*COLL GROUP HORM F, 1996, LANCET, V47, P1713
[8]   INFERTILITY AND BREAST-CANCER - A POPULATION-BASED CASE-CONTROL STUDY [J].
GAMMON, MD ;
THOMPSON, WD .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 132 (04) :708-716
[9]  
Garland M, 1998, AM J EPIDEMIOL, V147, P636
[10]  
HANING RV, 1979, OBSTET GYNECOL, V54, P442