An immunohistochemical analysis of p27 expression in human pancreatic carcinomas

被引:18
作者
Hu, YX
Watanabe, H
Li, P
Wang, Y
Ohtsubo, K
Yamaguchi, Y
Sawabu, N
机构
[1] Kanazawa Univ, Canc Res Inst, Dept Internal Med & Med Oncol, Kanazawa, Ishikawa 9218044, Japan
[2] Changhai Hosp, Dept Clin Oncol, Shanghai, Peoples R China
关键词
pancreatic carcinoma; p27 protein expression; immunohistochemistry;
D O I
10.1097/00006676-200010000-00002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
p27 is known as one of the candidate tumor suppressor genes. Although abnormalities including deletion and mutation in this gene are rarely detected, loss of p27 expression has been reported to be correlated with the high degree of malignancy in many human cancers. In the present study, we investigated the status of p27 expression in human pancreatic carcinoma (PC) and assessed the clinicopathologic significance of loss of p27 expression in the development and progression of this malignancy using immunohistochemistry. No nuclear staining for p27 protein existed in 65 (65.7%) of the 99 PC tumors examined. Furthermore, loss of p27 expression was correlated with turner grade (G1 versus G2, or G3, p < 0.05) or clinical stage (I and II versus III and IV, p < 0.01). The above data suggest that loss of p27 expression is a very common event in PC, and moreover, this alteration might contribute to the progression of this malignant disease.
引用
收藏
页码:226 / 230
页数:5
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