DNA increases the potency of vaccination against infectious diseases

被引：8

作者：

Wahren, B ^{[1
]}

Brytting, M ^{[1
]}

机构：

[1] Karolinska Inst, Swedish Inst Infect Dis Control, Ctr Microbiol & Tumor Biol, S-10521 Stockholm, Sweden

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(97)80008-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past couple of years, the idea that naked DNA can be used to vaccinate against infections has been rapidly developing. In contrast to traditional protein or live attenuated vaccines, there is no risk of disease caused by DNA vaccines as only selected proteins are encoded. The ease with which DNA may be manipulated means that vaccines can be custom designed to meet many needs. In animal model systems, DNA vaccines have proved to be as effective as traditional vaccines. Additionally, this technology may also be used to control existing chronic infections. Possibilities for treating hepatitis B, herpes simplex virus-2 and HIV, as well as infections with parasites, are being explored with success. (C) Current Biology Ltd ISSN 1367-5931.

引用

页码：183 / 189

页数：7

共 59 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].