First catalytic asymmetric synthesis of β-amino-β-polyfluoroalkyl ketones via proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines

被引：54

作者：

Funabiki, K ^{[1
]}

Nagamori, M ^{[1
]}

Goushi, S ^{[1
]}

Matsui, M ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Mat Sci & Technol, Gifu 5011193, Japan

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 17期

关键词：

D O I：

10.1039/b406000h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Proline-catalysed direct asymmetric carbon - carbon bond formation reaction of polyfluoroalkylated aldimines with acetone afforded the corresponding beta-(p-methoxyphenyl) amino-beta-polyfluoroalkyl ketones in high enantioselectivities ( up to 98% ee).

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收藏

页码：1928 / 1929

页数：2

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