Synthetic studies on the DEF-rings of FR182877 and hexacyclinic acid

被引：25

作者：

Clarke, PA

Grist, M

Ebden, M

Wilson, C

Blake, AJ

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] AstraZeneca Charnwood, Med Chem, Loughborough LE11 5RH, Leics, England

来源：

TETRAHEDRON | 2005年 / 61卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

transannular; lodocyclisation; natural products; medium sized rings;

D O I：

10.1016/j.tet.2004.10.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of model DEF-rings of the polyketide anti tumor natural products FR182877 and hexacyclinic acid has been achieved. The key steps in the synthesis are an intramolecular Pd(0) catalyzed allylic substitution reaction, which was used to generate a 9-membered carbocycle, and a novel transannular iodocyclization reaction which furnished the DF-rings of both natural products. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：353 / 363

页数：11

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