A novel splice variant of the cell death-promoting protein BAX

被引:48
作者
Zhou, M [1 ]
Demo, SD [1 ]
McClure, TN [1 ]
Crea, R [1 ]
Bitler, CM [1 ]
机构
[1] Neurex Corp, Dept Cell Biol, Menlo Pk, CA 94025 USA
关键词
D O I
10.1074/jbc.273.19.11930
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell death plays an important role in a number of physiological processes in all complex multicellular organisms. One of the molecules that regulates this process is BAX, an integral membrane protein, that promotes apoptosis. The function of BAX is countered by BCL-2 and BCL-X-L. The differential expression of these proteins can influence the ability of the cell to die or survive. In this paper, we describe the cloning, biochemical, and functional characterization of a novel splice isoform of BAX, called BAX-omega. Transient overexpression of BAX-omega protein potentiates cell death at levels comparable to that of BAX-alpha overexpression.
引用
收藏
页码:11930 / 11936
页数:7
相关论文
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