Hepatocyte nuclear factor-4α mediates the stimulatory effect of peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

被引：58

作者：

Boustead, JN ^{[1
]}

Stadelmaier, BT ^{[1
]}

Eeds, AM ^{[1
]}

Wiebe, PO ^{[1
]}

Svitek, CA ^{[1
]}

Oeser, JK ^{[1
]}

O'Brien, RM ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Physiol & Mol Biophys, Sch Med, Nashville, TN 37232 USA

来源：

BIOCHEMICAL JOURNAL | 2003年 / 369卷 / 01期

关键词：

diabetes; gluconeogenesis; HNF-4; phosphoenolpyruvate carboxykinase;

D O I：

10.1042/BJ20021382

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has recently been shown that adenoviral-mediated expression of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1 alpha) in hepatocytes stimulates glucose-6-phosphatase catalytic subunit (G6Pase) gene expression. A combination of fusion gene, gel retardation and chromatin immunoprecipitation assays revealed that, in H4IIE cells, PGC-1alpha mediates this stimulation through an evolutionarily conserved region of the G6Pase promoter that binds hepatocyte nuclear factor-4alpha.

引用

页码：17 / 22

页数：6

共 48 条

[1] PGC-l-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells
Andersson, U
Scarpulla, RC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) : 3738 - 3749
[2] A RAPID MICROPREPARATION TECHNIQUE FOR EXTRACTION OF DNA-BINDING PROTEINS FROM LIMITING NUMBERS OF MAMMALIAN-CELLS
ANDREWS, NC
FALLER, DV
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (09) : 2499 - 2499
[3] Nuclear hormone receptors and gene expression
Aranda, A
Pascual, A
[J]. PHYSIOLOGICAL REVIEWS, 2001, 81 (03) : 1269 - 1304
[4] Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states - Gene structure and 5'-flanking sequence
Argaud, D
Zhang, Q
Pan, WS
Maitra, S
Pilkis, SJ
Lange, AJ
[J]. DIABETES, 1996, 45 (11) : 1563 - 1571
[5] BARZILAI N, 1993, J BIOL CHEM, V268, P25019
[6] Nutrient regulation of gene expression by the sterol regulatory element binding proteins:: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo
Bennett, MK
Osborne, TF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) : 6340 - 6344
[7] Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells
Canuto, RA
Ferro, M
Salvo, RA
Bassi, AM
Trombetta, A
Maggiora, M
Martinasso, G
Lindahl, R
Muzio, G
[J]. BIOCHEMICAL JOURNAL, 2001, 357 : 811 - 818
[8] Multiple promoter elements are required for the stimulatory effect of insulin on human collagenase-1 gene transcription -: Selective effects on activator protein-1 expression may explain the quantitative difference in insulin and phorbol ester action
Chapman, SC
Ayala, JE
Streeper, RS
Culbert, AA
Eaton, EM
Svitek, CA
Goldman, JK
Tavaré, JM
O'Brien, RM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) : 18625 - 18634
[9] The direct and indirect effects of insulin on hepatic glucose production in vivo
Cherrington, AD
Edgerton, D
Sindelar, DK
[J]. DIABETOLOGIA, 1998, 41 (09) : 987 - 996
[10] Chou Janice Yang, 2002, Current Molecular Medicine (Hilversum), V2, P121, DOI 10.2174/1566524024605798

← 1 2 3 4 5 →