Role of hormone-controlled Th1-and Th2-type cytokines in successful pregnancy

被引：203

作者：

Piccinni, MP ^{[1
]}

Scaletti, C ^{[1
]}

Maggi, E ^{[1
]}

Romagnani, S ^{[1
]}

机构：

[1] Univ Florence, Dept Internal Med, Immunoallergol Unit, I-50134 Florence, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 109卷 / 01期

关键词：

cytokines; hormones; pregnancy; LIF; progesterone; relaxin;

D O I：

10.1016/S0165-5728(00)00299-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of CD4+ helper T (Th) cells into type 1 (Th1) or type 2 (Th2) effecters, as characterized by their opposite pattern of cytokine production, can be influenced by several factors, including hormones. Progesterone promotes the production of IL-4 and IL-5, whereas relaxin promotes the production of IFN-gamma by T cells. Leukemia inhibitory factor (LIF), essential for embryo implantation, is up-regulated by IL-4 and progesterone. Moreover, the production of LIF and/or Th2 cytokines by decidual T cells contributes to the maintenance of pregnancy. Our results suggest that relaxin and progesterone may contribute to the regulation of the immune homeostasis during pregnancy. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：30 / 33

页数：4

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