Acyl CoA:cholesterol acyltransferase genes and knockout mice

被引：32

作者：

Farese, RV ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94141 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 02期

关键词：

D O I：

10.1097/00041433-199804000-00007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acyl coenzyme A:cholesterol acyltransferase (ACAT) (EC 2.3.1.26) is an enzyme, located in the endoplasmic reticulum of many types of cells, that catalyzes cholesterol ester formation from cholesterol and fatty acyl CoA substrates. Sterol esterification by ACAT or homologous enzymes is conserved in evolution dating back to yeast. The recent cloning of a human cDNA for ACAT, together with genome sequencing projects, has led to the identification of an ACAT gene family and provided molecular tools for determining ACAT's functions in vivo. Summarized here is the current knowledge concerning the molecular genetics of ACAT. (C) 1998 Rapid Science Ltd.

引用

页码：119 / 123

页数：5

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