Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters

被引：93

作者：

Aslam, Saima

Trautner, Barbara W.

Ramanathan, Venkat

Darouiche, Rabih O.

机构：

[1] Michael E DeBakey VA Med Ctr, Infect Dis Sect, Med Serv, Houston, TX 77030 USA

[2] Baylor Coll Med, Infect Dis Sect, Dept Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Nephrol Sect, Dept Med, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期

关键词：

D O I：

10.1128/AAC.00893-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecy-cline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.

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收藏

页码：1556 / 1558

页数：3

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